One of the most important differences of integrative therapies, which is high-dose vitamin C, is applied in our personalized cancer treatment center by revealing the molecular action mechanisms and using the most modern treatments according to your tumor biology.
In other words, while your personalized treatment is designed by molecular tumor boards with the most advanced molecular examinations, you can receive personalized applications and treatments in ancient molecules and methods. You can get personalized dietary recommendations by illuminating the biology and molecular pathways of cancer.
After making all the analyzes of your cancer, we evaluate all the possibilities that can touch your life, discuss with you and design your treatment by giving effort.
You can get a second opinion from the medicana personalized cancer treatment center, where the same chemotherapy is not given to everyone on an organ basis, molecular analyzes are made on a genomic basis, and treatment decisions are made. You can get a second opinion for your molecular and/or comprehensive genomic profiling tests.
Vitamin C is a topic that has been talked about a lot in Turkey lately, is talked about a lot by cancer patients, is very curious and creates the agenda… When we say Vitamin C, we all immediately think of the use of Vitamin C, which dissolves in water, as an effervescent. But in this section, we will examine and scrutinize the vitamin C taken intravenously.
PubMed, which is closely known and referenced by the Medical World, is a platform with scientific articles. Doctors first scan from PubMED when they need to read articles for a research they want to do. Then, they can access its related journals and access the entire article. It is possible to reach many articles on intravenous Vitamin C administration in the scientific arena, which is a guide.
In sailors who stay at sea for a long time, especially the connective tissue is loosened and the vascular structures are damaged; There was a disease accompanied by bleeding. And it was called Scurvy.
The surgeon of the Royal Navy ship Dr. While at sea in May 1747, James Lind continues to consume apple cider vinegar, vinegar, sulfuric acid or sea water along with normal food to one group of sailors, while the other group provides crew members with 2 oranges and a lemon a day, unlike the others. In the history of science, this is considered the first controlled experiment in which results were compared by applying a single factor to a group of two populations while keeping all other factors the same. The results definitely showed that citrus fruits prevent the disease. Dr. Lind published this work in his dissertation on scurvy in 1753.
In the following years, Austrian Scientist Dr. Vitamin C became known with the invention of Albert Szent-Györgyi. Vitamin C’s relationship with cancer has always been questioned. But the person who asked this question most seriously was Linus Pauling, a two-time solo Nobel laureate. Vitamin C was known to strengthen the connective tissue structure. That’s why there was always the idea that cancer would thicken the walls around it and prevent the cancer from spreading. And for this reason, it was thought that Vitamin C would be effective in the treatment and prevention of cancer.
In their scientific research published by Linus Pauling and Scottish Surgeon Cameron in 1976 and 1978 (Proc Natl Acad Sci US A. 1978 Sep;75(9):4538-42.), they found that 100 advanced cancer patients who received high-dose vitamin C’ intravenously lived 300 days longer than patients with similar characteristics. In this study, patients with advanced incurable cancers, including bowel, stomach, kidney, breast, lung, and ovarian cancers, were included.
They showed that intravenous high-dose vitamin C therapy in all cancer types benefited patients. It was very important at that time. Because, against cancer, in an environment where many chemotherapy drugs are not yet available, you could gain advantage with Vitamin C.
The main point in this study was the intravenous administration of Vitamin C as a high dose.
The criticism of this study is that it is not done with two arms at the same time, as in many scientific studies. In other words, a comparison was not made without applying vitamin C to a group of patients and not applying it to another group; Comparisons were made with previous data. Pauling and Cameron, on the other hand, gave vitamin C intravenously to a single group of incurable patients and compared them with previous data with similar properties.
In the 1980s, two scientists named Moertel and Creagan from Mayo Clinic conducted two studies. They examined the role of vitamin C in the treatment of bowel cancer. But there were two important differences with Pauling’s method. While Linus Pauling administered high-dose vitamin C intravenously, Mayo Clinic researchers administered only short-term vitamin C by mouth. The study designs, unlike Pauling and Cameron, were two-armed.
With these approaches, Pauling and Cameron differed from the subject in which they were criticized, and it was claimed that their work contained more valuable information. For this reason, their studies were published in well-known scientific journals as articles (NEJM; New England Journal of Medicine).
The scientific world put aside Linus Pauling’s work:
· One-sided work
· There is no group to compare with
· Benchmarking based on past experience
On the other side were Moertel and Creagan from the Mayo Clinic:
Comparison between two groups
· Up-to-date benchmarking
The doctor does not know to whom he gave what medicine
With the second scientifically accepted study, it was concluded that Vitamin C did not work at all. At that time, the scientific world excluded Linus Pauling.
As a result of the conflict between these two studies, the discovery of the therapeutic functions of Vitamin C was blocked. This was indeed one of the most important wastes of time for the scientific world. Because when we look back and evaluate how Moertel and Creagan, the Mayo Clinic, have done this study before, we came across something very interesting…
The most important difference between these two studies is that while Pauling and Cameron applied their treatments intravenously as 10 g and for a long time, Moertel and Creagan applied their treatments only orally and for a short time (2.5 months). At this point, one of the most important debates in the scientific world began.
Immediately after the study by Moertel and Creagan, Moertel published that another drug had very successful results in colon cancer, and that drug called ‘Levamisole’ entered the standard of bowel cancer treatment.
This development raises many questions:
· Due to the fact that the drug called Levamisole is patented and produced by a company, was Vitamin C, which does not require a patent and cannot earn a lot of money, sacrificed to this drug?
· Why did Moertel and Creagan specifically choose oral administration when designing this study?
· What was the reason for their short-term practice?
Did they set out knowing that Vitamin C would not work when applied with this design?
· When there was an exemplary scientist like Pauling, did they deliberately ignore his research?
· Did they really do these works amateurishly without evaluation and examination?
When we came to 1989, the Vitamin C debate was being continued and kept warm, especially by a group that believed in the scientificness of Vitamin C. It was an unexpected and surprising development. The biology and molecular biology students of the Mayo Clinic, where Moertel and Creagan thought they had eliminated Vitamin C by doing their work, invited Linus Pauling to their graduation ceremony. And Linus Pauling gave the speech at the graduation ceremony at the Mayo Clinic. The students both honored Pauling and glorified Vitamin C.
Immediately after this invitation, Linus Pauling and his colleague Hermann decided to examine the studies with the statistical method Hardin Jones criteria. Thanks to this method, they evaluated the effectiveness studies of drug analyzes and analyzed how accurate data this study was and how valuable and reliable it was. They set three criteria. And studies that met all three of these three criteria were considered valuable studies. They analyzed over 200 studies with this method. And almost all of them fulfilled these 3 criteria. Except for one study… You were wondering, right?
Yes, your guess is right… MOERTEL’s Vitamin C studies were designed incorrectly and their results should have been ignored. Pauling also sent these scientific studies to the NEJM journal, but they chose not to publish it without any justification. However, they published this in the journal of the American Academy of Sciences (L Pauling and Z S Herman PNAS September 1, 1989. 86 (18) 6835-6837).
Pauling said that it cannot be said with these publications that vitamin C is not different from placebo. And it was not answered. Because Moertel was busy getting FDA approval for the worm medicine Levamisole, it had achieved its purpose.
Pauling wrote about these issues in his book:
“The Mayo Clinic doctors refused to discuss these issues with me. I think they are not scientists, they are not dedicated to the search for truth. I think they are ashamed of themselves and prefer to forget about the issue. The Mayo clinic used to have considerable prestige. However, this process has shown me that it does not deserve it anymore.”
Pauling, How to Live Long and Feel Good (Pauling 1986)
However, Pauling’s efforts at the age of 80 paved the way for many studies on Vitamin C. Work continued in Japan, Germany and other countries.
In a study published at the end of 2015, Scientist Lewis Cantly showed that Vitamin C enters the cell and selectively kills the tumor, especially in intestinal cancer tumors with mutant KRAS and BRAF genes. Immediately afterwards, in the studies of Dr Allen and his friends from the University of Iowa in April 2017, all the mechanisms of action of Vitamin C were revealed very clearly. More importantly, the American Cancer Institute, which has been against Pauling for years, donated $9.7 million to the University of Iowa to support Vitamin C thousand cancer studies.
Vitamin C is very tightly controlled as it is absorbed from the intestines. Since it is very tightly controlled, the amount passed into your blood is very low even if 1gr is taken orally or 1 sack is eaten. At this concentration, the effect of Vitamin C shows antioxidant properties. In tumors, doctors do not want to use antioxidants. Because the tumor constantly produces acid, oxidation is at a high level. Clearing this oxidation can facilitate the work of the tumor.
Vitamin C is a pro-oxidant when administered intravenously. That is, hydrogen peroxide reverts to a state that produces oxygenated water. If we consider hydrogen peroxide as a powerful cleaning agent; We can compare it to bleach. More interestingly, the hydrogen peroxide produced by vitamin C is selectively produced only around tumor cells and has a direct toxic effect on the tumor. It only kills cancer cells; does not kill normal cells. For this reason, high-dose Vitamin C intravenously means that we are no longer just talking about a vitamin, but a pro-drug. Vitamin C administered intravenously in pharmacological doses is a prodrug.
The first reason why Vitamin C can distinguish a normal cell from a cancerous cell is the enzyme Catalase found in our blood and tissues. The Catalase Enzyme quickly converts hydrogen peroxide, that is, oxygenated water, into water and oxygen. However, this enzyme is almost absent in cancer cells. For this reason, cancer cells cannot remove hydrogen peroxide from the environment like normal cells.
The second reason is that when metals and hydrogen peroxide combine, they directly form free oxygen radicals, attacking and killing tumor DNA. In normal cells, the iron molecule is less than in cancer cells. Iron is one of the elements that ensures the survival of cancer stem cells. Increased iron combined with hydrogen peroxide selectively kills cancer cells.
Vitamin C is a very interesting molecule. It is 90-95% similar to sugar. If blood sugar is measured in people taking vitamin C, the rate is high, because many machines cannot distinguish between sugar and vitamin C. Cancer cells do not use oxygen; It feeds on sugar alone, using 200 times more sugar than a normal cell. Therefore, when Vitamin C is given intravenously, it enters into cancer cells just like sugar.
You can think of it in the same way as the technical working system of PET CT/MR, which is taken to detect cancerous cells. Fluorine is attached to sugar to draw PET Film. The fluorine we bind is like a signal that indicates the location of the cancer. When you give fluorinated sugar intravenously, all the sugar is attracted by the cancer cells and shines in the film because the fluorine is bound. And those glowing cells are diagnosed as tumors. Therefore, Vitamin C has a very important role in cancer.
Even at very high doses, Vitamin C is excreted in the urine, as it is a water-soluble vitamin. There are only two rules:
If these rules apply, it can be said that Vitamin C has almost no side effects. The desired dose can be applied to the cancer patient by the doctor. There is no need for high doses for a healthy person. The purpose of administering high doses to cancer patients is that the pharmacological dose creates hydrogen peroxide in the blood.
However, some patients may experience discomfort when the Vitamin C concentration rises in intravenous intake. For this reason, a test dose of 15 g should be applied first. It should not be thought of as an allergy test to see side effects. To set the starting dose only, the reference point is set. Then the dose of Vitamin C is gradually increased. For example, if the target dose is 100gr, 100gr is not applied directly. First start with 25gr. Then it is increased to 50gr, 75gr and 100gr. Target doses above 50 g are definitely not started in the first application.
Vitamin C has a thirst-quenching effect as it increases urination. For this reason, it is recommended that patients drink water before the application. In addition, during the Vitamin C infusion, patients are definitely given oxygen. Thus, by increasing the free oxygen radicals formed inside, Vitamin C is provided to be more effective.
High-dose vitamin C products have been approved in Canada, Chile, and New Zealand since 2010. In addition, 25 gr/50 ml vials were approved by the FDA in the USA in 2017. In FDA reports, it is stated that it is safe up to a dose of 187 g/day.
Even more successful results are obtained when vitamin C is used with chemotherapy agents in the treatment of cancer patients. Vitamin C enhances the effect of chemotherapy. There are also some chemotherapy drugs that cannot be used. The reason for this is again explained by the functioning of the kidneys. Vitamin C also reduces the side effects of chemotherapy agents with which it can be used.
Especially in some types of cancer, smart drugs are used. For example, smart drugs are mostly preferred in bowel cancers. By looking at the EGFR pathway, by looking at the KRAS gene, effective drugs are selected accordingly. If these drugs are applied together with Vitamin C, much better results can be obtained.
Riordan Clinic is one of the clinics that performs Vitamin C application most frequently and has the highest number of cases. But the study of Dr Allen at the University of Iowa has revealed all the working principles of Vitamin C as well as showing all the mechanisms of action. Intravenous high-dose Vitamin C administration has proven to be safe and effective in both lung and brain tumors, along with chemotherapy and radiotherapy in cancer patients. When both phase 1 and phase 2 results of the studies were published, they were widely covered in medical journals.
In the state of Kansas, high-dose vitamin C therapy is administered at both the Riordan Clinic and the University of Kansas. The University of Kansas has a Vitamin C Infusion Clinic. One of the prominent names of this hospital, Dr. Levin, together with the head of the Department of Integrative Medicine at the University of Kansas, showed that Vitamin C enhances the treatment effects of chemotherapy. As a result of these studies, 25 g Vitamin C preparations were approved by the FDA in November 2017 and started to be used under license in the USA.
In the studies conducted by Samsung Hospital in South Korea on Vitamin C, it was revealed that when healthy people are treated with certain periods, they get sick less, they recover faster and their work efficiency increases. For this reason, especially in America, some countries of Europe, and South Korea, intravenous vitamin C is administered in non-serious viral infections and infections and at certain periods. It is a treatment that can be taken in cases of chronic fatigue. Besides its health effect, Vitamin C is ergogenic; gives energy. It also helps release endorphins. It makes the person feel good.
In chemistry there are Fenton reactions. Fenton reaction in many areas where chemistry serves; It is used in many fields such as textile and industry.
The basic mechanism is hydrogen peroxide, H2O, iron +2, iron +3 conversion in the environment, with the electron it gives off, and hydroxyl radicals form. They are also used in whitening and cleaning. When we look at the relationship with Vitamin C; ascorbic acid, namely Vitamin C, is the only molecule in nature that can donate 2 electrons. When it gives this electron, Iron +3 turns into Iron +2. And while this converted Iron +2 turns into Iron +3 again, the hydrogen peroxide formed by ascorbic acid in the environment provides the formation of hydroxyl radicals in the environment. In other words, Vitamin C first forms hydrogen peroxide and then hydroxyl radicals.
Hydrogen peroxide can also occur in our normal tissues. But it quickly turns it into water and oxygen with our existing enzymes. Since enzymes called catalase are not present in cancerous tissues, cancerous tissues cannot remove hydrogen peroxide formed by Vitamin C ascorbic acid. As a result, when you are infused, ascorbic acid donates its electron and turns into hydroxy ascorbate, while iron +3, iron +2 conversion hydroxy radicals are formed.
The excess iron molecules in cancer cells cause more interaction with hydrogen peroxide. Since the enzyme catalase is also deficient, the hydroxyl radicals formed selectively affect cancer cells. This is also called intravenous C Redox Chemotherapy due to reduction.
In summary, Fenton Reaction;
· During the conversion of ascorbic acid to dihydroxy ascorbate, hydrogen peroxide is formed in the presence of oxygen.
Because Vitamin C is very similar to sugar, it enters through the sugar channel. The same transformation occurs inside the cancer cell.
Together with the increased iron pool called ‘labile iron pool’, the hydroxyl radicals formed directly attack DNA and mitecontries and selectively kill cancer cells.
Vitamin C therapy selectively creates free oxygen radicals in cancer cells and causes damage to cancerous cells.
In the April issue of 2017’s Cancer Cell Journal, Dr. The study of Allen et al. has examined this issue in detail.
How Is Intravenous (Intravenous) Vitamin C Administered?
In particular, the infusion set must be protected from light when administering Vitamin C. A special colored set is used for this. In addition, since Vitamin C is a vitamin that deteriorates very quickly when left exposed, the IV bag must be protected from light.
The effect of Vitamin C lasts about 24 hours. It strengthens the immune system, especially against antiviral infection. It gives a better state of well-being the next day of application. In case of illness, it accelerates the healing process.
The main purpose of applying much higher doses when performing oncological treatments is to benefit directly from the tumor-killing effect, rather than to strengthen the immune system.
Excess vitamin C is not retained in the body, but is excreted through the urine. Pure Vitamin C does not smell in the urine.
Paraben-containing products can be used in applications that are said to be given as high-dose Vitamin C in wellness centers operating under the name of “Well Being”. When administering high doses of vitamin C, you may also be exposed to high doses of parabens.
The residence time of Vitamin C in the blood does not exceed 8 hours. Even if higher doses are given, this process only takes a little longer. If you really took Vitamin C, you would feel the need to urinate immediately.